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Former researcher at OpenAI launches training data startup, argues that scaling AI alone is not enough

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Andrew Ho, who left OpenAI after eight months, launched a startup to create specialized training data for bioinformatics and laboratory work. In his view, targeted data collection will require over 100 billion dollars because scaling models alone will not solve the generalization problem.

Andrew Ho left OpenAI after eight months convinced that large language models generalize poorly and perform inconsistently even in well-covered areas such as programming. In his view, the main cause is a lack of training data for economically valuable skills, which are only marginally represented in existing datasets. Ho argues that scaling alone will not solve this problem and estimates that AI labs will have to invest over 100 billion dollars in targeted data collection in the coming years. He also says he is skeptical of the high valuations of leading labs such as OpenAI or Anthropic, which he describes as chronically unprofitable because they need to continually invest in new models to maintain their lead over cheaper competitors such as Qwen or Kimi.

The first products from his startup target two areas: datasets for complex analyses in bioinformatics, where, according to the figures cited, even current models such as GPT-5.6 Sol achieve a success rate of only around 30 percent, and datasets for routine laboratory work, such as AI models evaluating photographs of experiments. According to the company, chemistry, materials science, healthcare, and more general knowledge work are set to follow.

Adam Hunt, a researcher at University of Cambridge, shares a similarly skeptical view. He argues that the latest models are becoming more specialized rather than more versatile: they are improving in programming and complex mathematics, while language quality and basic logic are stagnating or deteriorating. According to Hunt, this is because reinforcement learning works well in areas with clear rewards and complete training data, such as code, while such data is lacking elsewhere. However, he puts his own confidence in this pessimistic thesis at only around 40 percent. In the position paper “LLMs can't jump”, Tom Zahavy from Google DeepMind offers a structural explanation: models are good at deduction and induction but fail at creative abduction, meaning the ability to come up with a cause for which no linguistic precedent yet exists. According to the source, the debate over whether models are capable of true generalization beyond their training data remains unresolved.

What changed

Why it matters

If this thesis is confirmed, it means that the reliability of AI models will vary significantly across domains depending on whether high-quality training data and verifiable rewards exist for them – this provides concrete guidance for deciding where to deploy AI without human oversight and where not to.

Two audiences, two different impacts

What this means

01

For individuals

When working with AI outside programming and mathematics (e.g. specialized expert analysis), the arguments presented suggest that results should be verified, because, according to the source, model reliability in such domains is significantly lower.

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02

For a business

According to the source, companies considering deploying AI in specialized domains (bioinformatics, laboratory work, etc.) should expect lower model reliability where high-quality training data is lacking and monitor whether targeted datasets are being developed for their field.

Strategy
What to decide Check whether specialized datasets or benchmarks exist for the field in which the company deploys AI models.
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AI startup Andrew Ho bioinformatics LLM scaling OpenAI training data

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Event sources

only one source so far · 1 publisher, 1 independent. We count feeds from the same owner only once.

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The Decoder (daily AI news) independent context · first detected Ex-OpenAI researcher bets $100 billion will flow into training data because scaling alone won't cut it